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Frequent neurologic toxicity associated with amiodarone therapy
Neurology
|May 1, 1984
Summary
Amiodarone, used for ventricular arrhythmias, can cause a reversible neurologic syndrome in over half of patients. This syndrome, characterized by tremor and ataxia, is the most common reason for stopping the drug.
Area of Science:
- Cardiology
- Neurology
- Pharmacology
Background:
- Amiodarone is an effective antiarrhythmic drug for ventricular tachycardia and fibrillation.
- Refractory cases often require amiodarone, but its side effect profile needs further elucidation.
Purpose of the Study:
- To describe a specific neurologic syndrome associated with amiodarone therapy.
- To determine the frequency and characteristics of this adverse event.
Main Methods:
- Prospective observation of 54 consecutive patients treated with amiodarone.
- Detailed recording of neurologic symptoms and their relationship to amiodarone dosage.
Main Results:
- A reversible neurologic syndrome (tremor, ataxia, peripheral neuropathy) occurred in 54% of patients.
- This syndrome was the primary reason for dose alteration or discontinuation.
- Neurologic symptoms resolved within 2 days to 4 weeks after amiodarone reduction or cessation.
Conclusions:
- Frequent neurologic toxicity is a previously undescribed complication of amiodarone.
- Recognition of this syndrome can prevent unnecessary diagnostic workups.