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Expression of cellular oncogenes in human malignancies
Science (New York, N.Y.)
|April 20, 1984
Summary
This study investigated cellular oncogene expression in human tumors, finding multiple oncogenes active in all samples. Malignant tissues often showed higher oncogene activity than normal tissues, including the novel finding of fes oncogene activity in lung and blood cancers.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Cellular oncogenes are linked to cancer development in various models.
- Their role in human malignancies requires further investigation.
Purpose of the Study:
- To examine the expression of 15 cellular oncogenes in diverse human tumors.
- To compare oncogene activity in malignant versus normal human tissues.
Main Methods:
- Analysis of fresh human tumor samples from 54 patients across 20 tumor types.
- Quantitative assessment of oncogene transcriptional activity.
- Comparative analysis of oncogene expression in matched tumor and normal tissues.
Main Results:
- All examined tumors exhibited transcriptional activity of more than one cellular oncogene.
- Malignant tissues frequently displayed elevated oncogene activity compared to matched normal tissues.
- The cellular fes (feline sarcoma) oncogene was found to be active in lung and hematopoietic malignancies, a novel finding in mammalian tissues.
Conclusions:
- Cellular oncogene dysregulation is a common feature across various human cancers.
- Specific oncogenes, including fes, show promise as biomarkers or therapeutic targets in certain malignancies.