Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cisplatin-induced autonomic neuropathy.

C S Rosenfeld, L E Broder

    Cancer Treatment Reports
    |April 1, 1984
    PubMed
    Summary

    This study reports a rare case of autonomic neuropathy in a patient with bronchogenic carcinoma treated with cisplatin chemotherapy. Symptoms resolved after discontinuing cisplatin and using dextroamphetamine.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Exposure to extrinsic stressors, social defeat or bisphenol A, eliminates sex differences in DNA methyltransferase expression in the amygdala.

    Journal of neuroendocrinology·2017
    Same author

    Effects of a maternal high-fat diet on offspring behavioral and metabolic parameters in a rodent model.

    Journal of developmental origins of health and disease·2016
    Same author

    Homage to the 'H' in developmental origins of health and disease.

    Journal of developmental origins of health and disease·2016
    Same author

    Sex-dependent effects of developmental exposure to bisphenol A and ethinyl estradiol on metabolic parameters and voluntary physical activity.

    Journal of developmental origins of health and disease·2015
    Same author

    Effects of maternal diet and exposure to bisphenol A on sexually dimorphic responses in conceptuses and offspring.

    Reproduction in domestic animals = Zuchthygiene·2012
    Same author

    Effect of glucose concentration during in vitro culture of mouse embryos on development to blastocyst, success of embryo transfer, and litter sex ratio.

    Molecular reproduction and development·2012

    Area of Science:

    • Oncology
    • Neurology
    • Pharmacology

    Background:

    • Bronchogenic squamous cell carcinoma is a significant cause of cancer-related mortality.
    • Chemotherapy regimens, including cisplatin, are standard treatments for advanced lung cancer.
    • Autonomic neuropathy is a potential, though uncommon, adverse effect of certain chemotherapeutic agents.

    Observation:

    • A 57-year-old male patient with bronchogenic squamous cell carcinoma received a chemotherapy regimen including cyclophosphamide, doxorubicin, and cisplatin.
    • Following chemotherapy administration, the patient developed severe autonomic neuropathy.
    • The patient's symptoms included [specific symptoms if available, otherwise omit or generalize].

    Findings:

    • This case represents the first documented instance of cisplatin-associated autonomic neuropathy in the medical literature.
    • Discontinuation of cisplatin therapy led to the resolution of the patient's autonomic neuropathy.
    • Subsequent treatment with dextroamphetamine further aided in the recovery of autonomic function.

    Implications:

    • This report highlights the potential neurotoxicity of cisplatin, specifically its association with autonomic neuropathy.
    • Clinicians should be vigilant for signs of autonomic dysfunction in patients undergoing cisplatin-based chemotherapy.
    • Early recognition and management, including drug discontinuation and supportive therapies, may be crucial for patient recovery.

    Related Experiment Videos