Course of malignant catarrhal fever in immunosuppressed and immunostimulated rabbits

Rabbits pretreated with cyclophosphamide for 7 days (CY+) and control rabbits (CY-), were infected with cell-associated malignant catarrhal fever virus (MCFV), and CY treatment of the CY+ group was continued to day 20 p.i. The time of onset and degree of antibody formation to bovine serum albumin was significantly suppressed in the CY+ group whilst the humoral antibody response to MCFV appeared to be delayed rather than suppressed. Although incubation periods of the disease were comparable in the CY+ and CY- groups, the disease course was much shorter in the CY- group, 100% mortality occurring within a mean of 4.5 days, as opposed to a mean of 15 days in CY+ animals. Mortalities did not occur in the CY+ group until a mean of 5.5 days following withdrawal of CY. In further experiments it was shown that pre-existing antibody to MCFV had no effect on the incubation period and course of MCF in rabbits. The results thus suggest that MCF may not be an immune complex disease.