The effects of chlorpromazine, mianserin and Org GC94 on reproductive function in the rat

In the assessment of drug safety with respect to mammalian reproductive function chlorpromazine and two serotonin antagonists, mianserin (Org GB94 ) and Org GC94 were studied for their effects on ovulation and ovum transport. In addition, the effect of coitus on drug-induced ovulation inhibition was investigated. The compounds were intragastrically administered to Charles River CD rats in a single dose or in consecutive daily doses for one or two weeks. The incidence of ovulation and the number of eggs were recorded. The compounds blocked ovulation in pro-oestrous rats after a single dose. Ovulation was restored by coitus in drug-treated animals. The compounds appeared to become less effective in blocking ovulation after multiple dosing. No effects on ovum transport were detected. From the results obtained in this study, it is concluded that the CNS-active drugs investigated did not adversely affect reproductive function in the rat.