[Karyological characteristics of continuous mouse cell lines infected with the scrapie agent]

A karyological study of murine cell line L, latently infected with different strains of the scrapie agent (Compton and C-506) showed that the both variants number of chromosomes and the number of Robertson's translocations of chromosomes decrease insignificantly with an increase in the time of subcultivation. The use of the C-method of differential chromosome staining revealed four new analogous chromosomes in both experimental cell lines. This phenomenon is probably specific for this infected cell model.