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Updated: Jul 31, 2026
09:48
Development of Organoids from Mouse Pituitary as In Vitro Model to Explore Pituitary Stem Cell Biology
Published on: February 25, 2022
Summary
Cybernosis, or cybernetic disorders, can block neuro-endocrine feedback loops. This study examines tumoral and iatrogenic cybernosis, highlighting risks associated with correcting these feedback perturbations.
Area of Science:
- Neuroendocrinology
- Cybernetics
- Gerontology
Background:
- Cybernosis, defined as cybernetic functional disorders in senescence, involves negative feedback perturbation.
- Blocking cybernosis refers to disruptions in neuro-endocrine feedback loops caused by internal or external factors.
Purpose of the Study:
- To investigate tumoral and iatrogenic cybernosis using the hypothalamo-hypophyso-adrenocortical subsystem as a model.
- To differentiate between 'disorder' and 'blockade' in the context of cybernosis.
Main Methods:
- Analysis of the hypothalamo-hypophyso-adrenocortical subsystem.
- Examination of excessive corticoid secretion from adrenocortical tumors.
- Evaluation of negative feedback blockade from long-term high-dose steroid administration.
Main Results:
- Tumoral cybernosis: Adrenocortical tumors cause excessive corticoid secretion, blocking hypothalamo-hypophyseal control centers.
- Iatrogenic cybernosis: Long-term high-dose steroid therapy mimics natural corticoids, causing similar feedback blockade.
- Both tumoral and iatrogenic cybernosis result in subsystem 'turn off' without structural disorganization.
Conclusions:
- The term 'blockade' is more appropriate than 'disorder' for cybernosis due to lack of structural disorganization.
- Tumoral cybernosis observed in thyroid toxic adenoma, corticosteroid-secreting adenomas, and ovarian tumors.
- Iatrogenic cybernosis linked to long-term corticosteroid therapy for conditions like dermatoses and hirsutism.
- Correction of blocking cybernoses requires caution; sudden removal can lead to severe collapse and coma.
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