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Treatment of seizures with medroxyprogesterone acetate: preliminary report
Neurology
|September 1, 1984
Abstract:
Medroxyprogesterone acetate (MPA), a synthetic progesterone, was added to the antiepileptic drug regimen of 14 women who had uncontrolled seizures. Of the 11 women who developed amenorrhea, 7 reported fewer seizures during MPA therapy. Overall reductions in seizure frequency averaged 30% (n = 11), declining from a baseline 8.3 +/- 5.8 seizures per month to 5.1 +/- 4.1 seizures per month (p = 0.02). No serious side effects were encountered, but spotting was common. These preliminary data suggest further evaluation of MPA for catamenial seizures.
Keywords:
AmenorrheaAmericasBiologyCentral Nervous SystemCentral Nervous System EffectsClinical ResearchClinical TrialsConnecticutContraceptionContraceptive Agents, Female--administraction and dosageContraceptive Agents, Female--beneficial effectsContraceptive Agents, Progestin--administraction and dosageContraceptive Agents, Progestin--beneficial effectsContraceptive Agents--administraction and dosageContraceptive Agents--beneficial effectsContraceptive Mode Of ActionDepo-proveraDeveloped CountriesDiseasesEndocrine SystemFamily PlanningHormonesMedroxyprogesterone Acetate--administraction and dosageMedroxyprogesterone Acetate--beneficial effectsMenstruation DisordersNorth AmericaNorthern AmericaOvulation SuppressionPhysiologyProgestational HormonesProgesteroneProspective StudiesResearch MethodologyResearch ReportStudiesUnited States
