Atypical neuroleptics clozapine and thioridazine enhance amphetamine-induced stereotypy

The effects of the atypical neuroleptics clozapine and thioridazine and the typical neuroleptic pimozide on amphetamine-induced behavior were examined. Pimozide, as expected, blocked both amphetamine-induced locomotion and stereotypy. Thioridazine and clozapine antagonized the increases in locomotion produced by amphetamine, but produced increases in amphetamine-induced stereotypy and lowered the threshold dose for stereotypy. It is suggested that the increased stereotypy might partly account for the decreased locomotion, and that this might be a primary effect of these atypical neuroleptics. The data would also suggest that the use of amphetamine-induced stereotypy as a model for psychosis is inappropriate, as clozapine and thioridazine, which enhance stereotypy, are antipsychotic.