Synthesis and characterization of 2-(2-hydroxyphenyl)-4-aryl-1,5-benzodiazepines

Four benzodiazepine derivatives, reported earlier by other authors, were resynthesized and characterized by NMR, IR, GC/MS and elemental analysis. Three of the four compounds have melting points different from those initially reported by 35-70 degrees C. The differences in melting point along with the discrepancies in IR spectra between our samples and those previously reported suggest that at least three of the eight compounds reported to be 1,5-benzodiazepines have incorrect structural assignments.