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Postnatal development of kidney function in rats receiving thyroid hormones.

H Bräunlich

    Experimental and Clinical Endocrinology
    |May 1, 1984
    PubMed
    Summary
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    Toxicology·1995

    Thyroid hormones triiodothyronine (T3) and tetraiodothyronine (T4) enhance renal excretion of p-aminohippurate (PAH) in immature rats. This effect requires intact protein synthesis and is observed across various ages, indicating T3

    Area of Science:

    • Endocrinology
    • Nephrology
    • Developmental Biology

    Background:

    • Thyroid hormones play crucial roles in development and metabolic regulation.
    • Renal function, including the excretion of organic anions like p-aminohippurate (PAH), undergoes significant changes during maturation.
    • The impact of thyroid hormones on developing kidney function is not fully elucidated.

    Purpose of the Study:

    • To investigate the effect of thyroid hormones, specifically triiodothyronine (T3) and tetraiodothyronine (T4), on renal p-aminohippurate (PAH) excretion in immature and adult rats.
    • To determine the age-dependency and dose-dependency of this effect.
    • To explore the interaction with other drugs and the role of protein synthesis in mediating the hormonal influence.

    Main Methods:

    • Rats of various ages (from 2 days to 105 days old) were pretreated with T3 or T4.

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  • Dose-response and time-course studies were conducted.
  • Experiments involving simultaneous administration of cyclopenthiazide and T3 were performed.
  • Inhibitors of protein biosynthesis (azauracil, neomycin) were used to assess the role of protein synthesis.

    • Main Results:

    • Daily pretreatment with T3 or T4 increased renal PAH excretion in immature rats, with similar effects observed in rats aged 5 to 105 days.
    • The renal effect of T3 and T4 was not strongly dose-dependent.
    • Simultaneous administration of cyclopenthiazide and T3 was not more effective than either agent alone, particularly in young rats.
    • Inhibitors of protein biosynthesis antagonized the T3-induced stimulation of PAH excretion.
    • Data suggest T3 is effective in young rats and T4 can be converted to T3 in this age group.

    Conclusions:

    • Thyroid hormones (T3 and T4) effectively stimulate renal PAH excretion in rats across a wide age range, including immature animals.
    • Intact protein synthesis is a prerequisite for thyroid hormone-mediated stimulation of kidney function.
    • T4 conversion to T3 occurs in young rats, contributing to the observed effects.