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Diabetic myocardial alterations in ultrastructure and function.

M Z Koltai, I Balogh, M Wagner

    Experimental Pathology
    |January 1, 1984
    PubMed
    Summary
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    Diabetic dogs show increased collagen fibers and mitochondria in heart muscle, impacting cardiac function. These ultrastructural changes correlate with impaired glucose metabolism, suggesting collagen proliferation contributes to diabetic heart disease.

    Area of Science:

    • Cardiology
    • Diabetology
    • Cell Biology

    Background:

    • Diabetes mellitus is associated with cardiovascular complications.
    • Diabetic cardiomyopathy is a recognized clinical entity.
    • Understanding the cellular basis of diabetic heart dysfunction is crucial.

    Purpose of the Study:

    • To investigate the ultrastructural changes in the myocardium of alloxan-diabetic dogs.
    • To determine the correlation between cardiac function and glucose metabolism in diabetic dogs.
    • To elucidate the role of collagen fiber proliferation in diabetic myocardial dysfunction.

    Main Methods:

    • Percutaneous needle-biopsy of myocardial samples from healthy and alloxan-diabetic dogs.
    • Electron microscopic examination of myocardial ultrastructure.

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  • Hemodynamic investigation and measurement of plasma glucose disappearance rate.

    • Main Results:

    • Increased collagen fibers and mitochondria were observed in diabetic canine myocardium.
    • Widening of Z bands was noted in the diabetic myocardium.
    • A significant inverse correlation was found between left ventricular passive elastic modulus and plasma glucose disappearance rate.

    Conclusions:

    • Ultrastructural alterations, including collagen fiber proliferation, occur in the diabetic myocardium.
    • These changes are linked to impaired cardiac diastolic function.
    • Collagen fiber proliferation is implicated as a contributing factor to functional disorders in the diabetic heart.