[Hypersensitivity to VM-26]

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B Köster, J Ritter, U Bode

    Klinische Padiatrie
    |May 1, 1984
    PubMed

    Abstract:

    Life-threatening anaphylactic reactions to VM-26 are rare. In this report two patients with anaphylactic reactions after the first VM-26 applications in the German neuroblastoma therapy protocol GPO-NB-82 are described. After combination of VM-26 with dexamethasone, repetition of these reactions did not occur any more.

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    Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

    Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...

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