[Experimento-clinical basis for using papain in purulent surgery]

Area of Science:

• Biochemistry
• Wound Healing
• Surgical Practice

Background:

• Purulent processes pose significant challenges in wound healing.
• Effective proteolytic enzymes are needed for wound management.
• Papain is a proteolytic enzyme derived from plants.

Purpose of the Study:

• To evaluate the safety and efficacy of papain in treating purulent processes.
• To assess the proteolytic activity and wound healing effects of papain.
• To determine the suitability of papain for surgical applications.

Main Methods:

• Experimental injections of papain (5-36 mg/kg) to assess toxicity.
• Clinical use of 0.2-0.5% papain solution for local treatment of purulent wounds.
• Observation of wound healing phases and complication monitoring.

Main Results:

• Papain injections showed no toxic effects on the body or serous membranes.
• Clinical use demonstrated high proteolytic activity.
• Papain application shortened the initial phase of wound healing.
• No local or general complications were observed.

Conclusions:

• Papain is a safe and effective proteolytic agent for wound treatment.
• Papain accelerates the healing of purulent processes.
• Papain is a viable option for purulent surgery in various healthcare settings.