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Related Experiment Videos

The cell surface antigen locus, MIC2X, escapes X-inactivation.

P Goodfellow, B Pym, T Mohandas

    American Journal of Human Genetics
    |July 1, 1984
    PubMed
    Summary

    The MIC2X gene, located on the human X chromosome, escapes X-inactivation. This finding is significant for understanding X chromosome gene regulation and expression.

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    Somatic cell genetics, immunogenetics and gene mapping.

    Immunology today·2014

    Area of Science:

    • Genetics
    • Molecular Biology
    • Immunology

    Background:

    • The cell surface antigen recognized by the 12E7 monoclonal antibody is encoded by genes on both the human X (MIC2X) and Y (MIC2Y) chromosomes.
    • MIC2X is localized to the Xp22.3-Xpter region, and MIC2Y to the Ypter-Yq1.1 region.

    Purpose of the Study:

    • To investigate whether the MIC2X gene escapes X-inactivation in human cells.

    Main Methods:

    • Analysis of MIC2X expression in human cells with inactive X chromosomes.
    • Examination of structurally normal and abnormal inactive X chromosomes.

    Main Results:

    • The study demonstrates that MIC2X escapes X-inactivation.
    • This escape from X-inactivation occurs on both structurally normal and abnormal inactive human X chromosomes.

    Conclusions:

    • The MIC2X gene is subject to escape from X-inactivation.
    • This finding has implications for understanding gene regulation on the inactive X chromosome.

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