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The cell surface antigen locus, MIC2X, escapes X-inactivation
American Journal of Human Genetics
|July 1, 1984
Abstract:
Recently, it was shown that the cell surface antigen defined by the monoclonal antibody 12E7 is expressed by both the human X and Y chromosomes; the gene loci on the X and Y chromosomes are referred to as MIC2X and MIC2Y, respectively. It was also shown that MIC2X is located in the region Xp22.3----Xpter and MIC2Y is in the region Ypter-Yq1.1. Here, we show that MIC2X escapes X-inactivation on structurally normal and abnormal inactive human X chromosomes.
Insights
The MIC2X gene, located on the human X chromosome, escapes X-inactivation. This finding is significant for understanding X chromosome gene regulation and expression.
Area of Science:
- Genetics
- Molecular Biology
- Immunology
Background:
- The cell surface antigen recognized by the 12E7 monoclonal antibody is encoded by genes on both the human X (MIC2X) and Y (MIC2Y) chromosomes.
- MIC2X is localized to the Xp22.3-Xpter region, and MIC2Y to the Ypter-Yq1.1 region.
Purpose of the Study:
- To investigate whether the MIC2X gene escapes X-inactivation in human cells.
Main Methods:
- Analysis of MIC2X expression in human cells with inactive X chromosomes.
- Examination of structurally normal and abnormal inactive X chromosomes.
Main Results:
- The study demonstrates that MIC2X escapes X-inactivation.
- This escape from X-inactivation occurs on both structurally normal and abnormal inactive human X chromosomes.
Conclusions:
- The MIC2X gene is subject to escape from X-inactivation.
- This finding has implications for understanding gene regulation on the inactive X chromosome.