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Comparison between diurnal changes and changes induced by hydrocortisone and epinephrine in circulating myeloid
Abstract:
A significant increase from 8 AM to 3 PM was found in both myeloid progenitor cell (CFU-GM) and polymorphonuclear leukocyte (PMN) blood concentration in 45 normal subjects. Diurnal blood (CFU-GM and PMN changes were significantly correlated. Spontaneous diurnal changes in blood CFU-GM levels and in PMN were compared with the changes induced by i. v. administration of hydrocortisone (16 normal volunteers) and of epinephrine (10 normal volunteers). Diurnal changes in CFU-GM and PMN seem to follow a pattern similar to that induced by epinephrine administration. These findings suggest that diurnal changes in CFU-GM reflect mainly a shift of these cells between different blood compartments.
Insights
Daily fluctuations in myeloid progenitor cells (CFU-GM) and polymorphonuclear leukocytes (PMN) are correlated. These diurnal changes in blood cell counts appear to be influenced by epinephrine, suggesting a shift between blood compartments.
Area of Science:
- Hematology
- Immunology
- Chronobiology
Background:
- Blood cell concentrations exhibit diurnal variations.
- Myeloid progenitor cells (CFU-GM) and polymorphonuclear leukocytes (PMN) are key components of the immune system.
- Understanding diurnal patterns is crucial for interpreting hematological data.
Purpose of the Study:
- To investigate the diurnal changes in blood concentrations of CFU-GM and PMN in healthy individuals.
- To compare spontaneous diurnal variations with those induced by hydrocortisone and epinephrine.
- To elucidate the mechanisms underlying diurnal blood cell count fluctuations.
Main Methods:
- Studied 45 healthy subjects for diurnal blood concentration changes of CFU-GM and PMN.
- Administered intravenous hydrocortisone to 16 volunteers and epinephrine to 10 volunteers.
- Correlated spontaneous diurnal changes with induced changes.
Main Results:
- Significant increases in both CFU-GM and PMN blood concentrations were observed from 8 AM to 3 PM.
- Diurnal changes in CFU-GM and PMN were significantly correlated.
- Induced changes by epinephrine administration mimicked spontaneous diurnal patterns.
Conclusions:
- Diurnal variations in blood CFU-GM and PMN levels are significant and correlated.
- Epinephrine administration appears to influence these diurnal patterns.
- Findings suggest diurnal changes in CFU-GM primarily reflect cell shifts between blood compartments.