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Disappearance of the decrease in biting behavior induced by clenbuterol, a beta-adrenergic agonist, after chronic

H Frances, S Danti, A J Puech

    Pharmacology, Biochemistry, and Behavior
    |August 1, 1984
    PubMed
    Summary
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    The beta-adrenergic agonist clenbuterol initially reduced food interest in starved mice but this effect diminished with repeated doses. Chronic clenbuterol treatment prevented acute effects for up to 45 hours.

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Behavioral Science

    Background:

    • Beta-adrenergic agonists, such as clenbuterol, are known to influence metabolic processes.
    • Appetite regulation is a complex process involving various signaling pathways.
    • Understanding drug tolerance is crucial for therapeutic applications.

    Purpose of the Study:

    • To investigate the acute effects of clenbuterol on food intake in a mouse model.
    • To determine the development of tolerance to the appetite-suppressing effects of clenbuterol.
    • To assess the duration of tolerance following chronic clenbuterol administration.

    Main Methods:

    • Administration of clenbuterol to starved mice.
    • Repeated dosing regimens to assess tolerance development.

    Related Experiment Videos

  • Evaluation of food interest at various time points post-administration.

    • Main Results:

    • Acute clenbuterol administration (0.125 mg/kg) decreased food interest in starved mice within 30 minutes.
    • Repeated treatment with clenbuterol (0.25 mg/kg, twice daily) led to the disappearance of this effect.
    • Three chronic injections were sufficient to block the acute effect of clenbuterol for up to 45 hours.

    Conclusions:

    • Clenbuterol exhibits an acute anorectic effect in mice.
    • Tolerance to the appetite-suppressing effects of clenbuterol develops rapidly with repeated administration.
    • Chronic clenbuterol treatment induces a sustained period of non-responsiveness to acute doses.