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Age differences in cisplatinum nephrotoxicity.

D Appenroth, H Bräunlich

    Toxicology
    |September 28, 1984
    PubMed
    Summary
    This summary is machine-generated.

    This study investigated cisplatinum (CP) nephrotoxicity in Wistar rats of various ages. Younger rats (10-15 days old) showed less susceptibility to CP-induced kidney damage compared to older rats.

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    Area of Science:

    • Toxicology
    • Pharmacology
    • Nephrology

    Background:

    • Cisplatin (CP) is a widely used chemotherapy agent.
    • CP is known to cause nephrotoxicity, but age-related susceptibility is not fully understood.

    Purpose of the Study:

    • To investigate the impact of different cisplatinum (CP) doses on renal excretory functions in Wistar rats across various age groups.
    • To determine potential sex differences in CP-induced nephrotoxicity.
    • To assess age-dependent susceptibility to CP nephrotoxicity.

    Main Methods:

    • Male and female Wistar rats (5-105 days old) were administered three different doses of CP (0.15, 0.3, or 0.6 mg/100 g body wt) intraperitoneally.
    • Renal excretory functions were assessed three days post-administration.
    • Parameters measured included body weight, urine volume, excretion of osmotically active substances, p-aminohippurate, and proteinuria.

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    Main Results:

    • No significant sex differences in nephrotoxicity were observed.
    • A dose-dependent decrease in body weight occurred in all age groups.
    • In younger rats (5 days) and older rats (33-105 days), lower CP doses had minimal effects, while the highest dose (0.6 mg/100 g) significantly reduced urine volume and excretory functions, causing proteinuria.
    • In 10- and 15-day-old rats, lower CP doses were non-pathological, but the highest dose induced significant proteinuria in 15-day-old rats.

    Conclusions:

    • CP-induced nephrotoxicity is dose-dependent and affects renal excretory functions.
    • Younger rats, particularly 10-15 days old, appear less susceptible to CP-nephrotoxicity based on the measured parameters.
    • Further research is warranted to elucidate the mechanisms underlying age-related differences in CP nephrotoxicity.