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Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
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Somatomedin C response to growth hormone in psychosocial growth retardation

N E Holmes, S L Blethen, V V Weldon

    The American Journal of the Medical Sciences
    |September 1, 1984
    PubMed

    Insights

    Children with psychosocial growth retardation can produce somatomedin C when given growth hormone. Their poor growth response may stem from resistance to somatomedin C, not a production issue.

    Area of Science:

    • Pediatric Endocrinology
    • Growth Hormone Therapy
    • Biochemical Markers

    Background:

    • Psychosocial growth retardation is characterized by impaired growth potentially influenced by environmental factors.
    • Exogenous growth hormone (GH) is used to treat various growth disorders.
    • Somatomedin C (Insulin-like Growth Factor 1) is a key mediator of GH action.

    Observation:

    • Three children with psychosocial growth retardation showed increased serum somatomedin C levels after exogenous GH administration.
    • The somatomedin C response pattern was comparable to that of children with GH deficiency treated with the same GH regimen.

    Findings:

    • Children with psychosocial growth retardation demonstrate the capacity to synthesize somatomedin C in response to exogenous growth hormone.
    • The impaired growth response to GH in these children is unlikely due to an inability to produce somatomedin C.

    Implications:

    • This suggests a potential resistance to the biological actions of somatomedin C in psychosocial growth retardation.
    • Further research is warranted to explore the mechanisms of somatomedin C resistance in this population.
    • Understanding these mechanisms could lead to more targeted therapeutic strategies for growth disorders.

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