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[Automatic finger plethysmography as a human pharmacologic research tool. A methodologic study].

M Müller, M Isenschmid, M Bührer

    Arzneimittel-Forschung
    |January 1, 1984
    PubMed
    Summary
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    Digital plethysmography, a noninvasive tool, showed D/H-ratios unaffected by hot drinks but lowered by cold. Averaging results from healthy volunteers improves data reliability for pharmacological studies.

    Area of Science:

    • Cardiovascular Physiology
    • Pharmacological Assessment
    • Noninvasive Monitoring Techniques

    Context:

    • Digital plethysmography is utilized as a noninvasive method for pharmacological research.
    • Investigating the D/H-ratio of plethysmographic pulse waves for physiological insights.
    • Assessing the impact of external factors on plethysmographic measurements.

    Purpose:

    • To establish baseline digital plethysmography recordings in healthy volunteers.
    • To evaluate the effects of exogenous influences, such as beverages and medications, on plethysmographic parameters.
    • To determine the reliability of automated D/H-ratio analysis.

    Summary:

    • Nine healthy volunteers underwent digital plethysmography to analyze the D/H-ratio.
    • A hot beverage did not significantly alter the D/H-ratio, whereas a cold drink caused a decrease.

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  • The D/H-ratio tended to decrease over 3 hours, an effect mitigated by pindolol or dihydroergotamine, though individual variability persisted.

    • Impact:

    • Automated evaluation of plethysmographic recordings demonstrates potential for pharmacological research.
    • Averaging data from multiple volunteers enhances the reliability of findings from automated plethysmography.
    • This study provides a foundation for using digital plethysmography in drug efficacy assessments, particularly for organic nitrates.