Estradiol and progesterone suppress feeding induced by 2-deoxy-D-glucose

The feeding response to 2-deoxy-d-glucose (2DG) was measured in gonadally intact females (NORM) during estrus (EST) or diestrus (DIES) and in ovariectomized (OVEX) rats following injections of estradiol benzoate and progesterone (HORM) or oil (OIL). In both groups the response to 2DG under conditions of EST or HORM was significantly suppressed relative to DIES or OIL. The suppressant effect of hormones on 2DG feeding was not accounted for by the suppressant effects of ovarian hormones on ad lib feeding or a function of the body weight of the subject. The results are discussed in the context of ovarian hormonal effects on glucostatic control of feeding.