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Related Experiment Videos

Substructures of neurofilaments.

G Y Wen, H M Wisniewski

    Acta Neuropathologica
    |January 1, 1984
    PubMed
    Summary

    Mammalian neurofilaments are composed of four protofilaments, forming a complex four-stranded helical structure. This detailed investigation reveals the globular units and connecting bars that define neurofilament architecture.

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    Area of Science:

    • Cell Biology
    • Neuroscience
    • Structural Biology

    Background:

    • Neurofilaments are key components of the neuronal cytoskeleton.
    • Understanding neurofilament structure is crucial for elucidating neuronal function and disease.

    Purpose of the Study:

    • To elucidate the detailed three-dimensional structure of mammalian neurofilaments.
    • To characterize the arrangement of protofilaments and their subunits.

    Main Methods:

    • High-resolution electron microscopy was used to examine neurofilaments from human and rabbit.
    • Cross-sectional and longitudinal views were analyzed to determine structural organization.

    Main Results:

    • Mammalian neurofilaments consist of four protofilaments, each formed by globular units and longitudinal bars.
    • A cross-view shows four globular units (20-25 Å) connected by four transverse bars (25-30 Å).
    • Neurofilaments exhibit a four-stranded helical structure with an axial periodicity of 200-270 Å.

    Conclusions:

    • The study presents a detailed model of neurofilament structure, revealing its four-stranded helical organization.
    • This structural understanding provides a basis for further research into neurofilament assembly and function.

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