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Related Experiment Videos

[Biochemical and x-ray changes in thyroid osteopathy].

R Baleva, L Dianov, S Frantsov

    Vutreshni Bolesti
    |January 1, 1978
    PubMed
    Summary

    Thyrotoxicosis patients show abnormal calcium levels and bone changes, particularly osteoporosis in women. This suggests impaired calcium regulation and highlights the need for further research into bone metabolism in thyroid disorders.

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    [Idiopathic osteoporosis at an early age].

    Vutreshni bolesti·1977

    Area of Science:

    • Endocrinology
    • Metabolic Bone Disease

    Background:

    • Thyrotoxicosis, a condition of excess thyroid hormones, can impact calcium and bone metabolism.
    • Previous studies suggest a link between hyperthyroidism and altered calcium homeostasis and bone density.

    Purpose of the Study:

    • To investigate calcium metabolism and bone changes in patients with confirmed thyrotoxicosis.
    • To assess the functional capacity of calcium-regulating systems in thyrotoxicosis.

    Main Methods:

    • Studied 50 patients with clinically confirmed thyrotoxicosis.
    • Assessed serum calcium, urine calcium excretion, phosphate clearance, and alkaline phosphatase.
    • Performed calcium loading tests and analyzed X-ray changes, including bone densitometry (Meema-Heunk method).

    Main Results:

    • Patients exhibited moderately elevated serum calcium, increased urinary calcium, and elevated alkaline phosphatase.
    • Calcium loading revealed exaggerated serum calcium elevation and delayed normalization, indicating impaired hypocalcemic regulation.
    • Osteoporosis was observed in 64% of females and 20% of males, increasing with age and disease severity. Intracortical striation was noted in 56.7% of patients.

    Conclusions:

    • Thyrotoxicosis is associated with significant disturbances in calcium metabolism and a high prevalence of osteoporosis, particularly in females.
    • The findings suggest an insufficiency in the body's calcium-regulating systems, specifically those involving calcitonin, in thyrotoxicosis patients.
    • Bone changes, including intracortical striation, are common and correlate with disease severity and patient demographics.

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