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Atrial natriuretic factor is a circulating hormone.

J Gutkowska, K Horký, G Thibault

    Biochemical and Biophysical Research Communications
    |November 30, 1984
    PubMed
    Summary
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    This study measured immunoreactive atrial natriuretic factor (IR-ANF) in rat plasma using radioimmunoassay. Results confirm that atrial cardiocytes secrete ANF into circulation, establishing the heart as an endocrine organ.

    Area of Science:

    • Endocrinology
    • Cardiovascular Physiology

    Background:

    • Atrial natriuretic factor (ANF) is a hormone involved in cardiovascular regulation.
    • Accurate measurement of ANF in plasma is crucial for understanding its physiological roles.

    Purpose of the Study:

    • To determine the concentration of immunoreactive ANF (IR-ANF) in rat plasma.
    • To investigate the secretion of ANF by atrial cardiocytes.

    Main Methods:

    • Radioimmunoassay (RIA) was employed for IR-ANF determination.
    • Immunoaffinity chromatography using Sepharose-4B anti-ANF and Vycor glass were used for plasma extraction.

    Main Results:

    • Mean IR-ANF concentrations were quantified in male and female rats.
    • A close linear correlation was found between IR-ANF levels in aortic and jugular venous plasma.

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  • Extraction method influenced measured IR-ANF concentrations.

    • Conclusions:

    • Atrial cardiocytes actively secrete atrial natriuretic factor into the bloodstream.
    • These findings support the classification of the heart as an endocrine organ.