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Is the hypertensive rat really hyperreactive?

J R Sutterer, C M Stoney, M Sanfillipo

    Hypertension (Dallas, Tex. : 1979)
    |November 1, 1984
    PubMed
    Summary
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    Spontaneously hypertensive rats (SHR) generally show higher activity than normotensive Wistar-Kyoto (WKY) rats. However, WKY rats exhibit greater behavioral reactivity to environmental stimulation changes than SHR.

    Area of Science:

    • Behavioral neuroscience
    • Physiology

    Background:

    • General activity is often used as an index of behavioral reactivity to environmental stimulation.
    • This reactivity is hypothesized to correlate with blood pressure elevation in spontaneously hypertensive rats (SHR) but not normotensive Wistar-Kyoto (WKY) rats.

    Purpose of the Study:

    • To investigate differences in behavioral reactivity to environmental stimulation between hypertensive-prone (SHR) and nonhypertensive-prone (WKY) rat strains.
    • To determine if general activity levels in SHR and WKY rats differ under varying degrees of environmental stimulation.

    Main Methods:

    • Assessed general activity (walking, rearing, shuttlebox crossings) in SHR and WKY rats.
    • Activity was measured in an open field and shuttlebox under constant and varying levels of environmental stimulation.

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    Main Results:

    • SHR rats consistently displayed higher activity levels than WKY rats under constant environmental stimulation.
    • WKY rat activity decreased as stimulus intensity increased, while SHR activity remained constant across all tested stimulus intensities.

    Conclusions:

    • While SHR rats are generally more active, WKY rats demonstrate a more pronounced behavioral reactivity to changes in environmental stimulation intensity.
    • Behavioral reactivity patterns differ between SHR and WKY rat strains, suggesting distinct responses to environmental challenges.