Brain capillaries: a target for inorganic lead poisoning
Related Experiment Video
Updated: Aug 23, 2026

Isolation of Cerebral Capillaries from Fresh Human Brain Tissue
Published on: September 12, 2018
Abstract:
Like nutrients and waste products, toxic metals enter and leave the brain by passing through the endothelial cells of brain capillaries. In contrast to most systemic organs, the endothelial cells of the brain microvasculature are sealed together by tight junctions. The result is a blood-brain barrier produced by a continuous layer of endothelial cells. Since heavy metals most likely pass through these cells to enter the brain, it is not surprising that the metals may accumulate within and injure the capillary cells. This review will consider some of the features that distinguish endothelial cells in the brain from those in systemic organs. Special consideration will be given to processes shown in the Figure which may influence the transport and toxicity of inorganic lead.
Related Concept Videos
The Blood-brain Barrier
Physiological Barriers
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
Capillaries and Their Types
Hemorrhagic Stroke ll: Pathophysiology
Cerebral Edema ll: Pathophysiology
Hepatic Encephalopathy

