Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[X-linked lymphoproliferative syndrome].

R S Weening, D J van Zaane, M K Sanders

    Tijdschrift Voor Kindergeneeskunde
    |December 1, 1984
    PubMed
    Summary

    A rare genetic disorder, X-linked lymphoproliferative syndrome (XLP), caused fatal Epstein-Barr virus infections in a young boy. This condition mimics acquired immunodeficiency syndrome (AIDS) and highlights the importance of genetic susceptibility in viral outcomes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Fatal venous air embolism during upper endoscopy in a patient with percutaneous transhepatic cholangiography (PTC) catheter.

    Endoscopy·2010
    Same author

    [Neonatal respiratory distress caused by primary ciliary dyskinesia].

    Nederlands tijdschrift voor geneeskunde·2006
    Same author

    Treatment strategy and results in children treated on three Dutch Childhood Oncology Group acute myeloid leukemia trials.

    Leukemia·2005
    Same author

    Effectiveness of acute postoperative pain management.

    British journal of anaesthesia·2003
    Same author

    Acute pain services--how effective are we?

    Anaesthesia·2002
    Same author

    Multicompartment block in a parturient undergoing urgent Caesarean section.

    European journal of anaesthesiology·2002

    Area of Science:

    • Immunology
    • Genetics
    • Virology

    Background:

    • This case report details a fatal case of Epstein-Barr virus (EBV) infection in a young child.
    • The patient's family history revealed the loss of three previous children with similar symptoms.
    • Consanguineous parentage (first cousins) was noted in the family history.

    Observation:

    • The 2.5-year-old Turkish boy presented with overwhelming infectious mononucleosis.
    • Acquired immunodeficiency was diagnosed, likely triggered by EBV in a genetically susceptible individual.
    • Clinical, serological, immunological, and histological findings were consistent with X-linked lymphoproliferative syndrome (XLP).

    Findings:

    • The patient's condition and family history strongly suggested X-linked lymphoproliferative syndrome (XLP).
    • Immunological findings bore resemblance to those observed in acquired immunodeficiency syndrome (AIDS).
    • Genetic predisposition to Epstein-Barr virus (EBV) was implicated as a key factor.

    Implications:

    • This case underscores the critical role of genetic factors in determining the severity of viral infections.
    • Early diagnosis and genetic counseling are crucial for families with a history of XLP.
    • Further research into the interplay between genetics and viral pathogenesis is warranted.

    Related Experiment Videos