[Hydrolysis of the antiemetic alizapride]

First order rate constants of the hydrolysis of N-[(1-allyl-2-pyrrolidinyl)-methyl]-6-methoxy-1H-benzotriazole-5-carboxa mide (alizapride, Vergentan) in acid and alkaline medium were determined. The activation energy observed in alkaline solution was 60.3 kJ X mol-1. The substance was not hydrolized in vitro by esterase, liver homogenate and plasma.