Haemopoiesis by clonal succession?

Alloenzymes of phosphoglycerate kinase (Pgk-1A and 1B), an X-linked enzyme of the glycolytic pathway that is expressed on all somatic cells, were used to study properties of developmentally early haemopoietic cells of mice (high proliferation potential colony-forming cells, HPP CFC) This study showed that: The colonies formed by HPP CFC are clones; There are distinct populations of HPP CFC that can respond to different haemopoietic growth factors; There are substantial differences in the proportions of Pgk alloenzymes of similar sets of HPP CFC found in similar and neighbouring bones; and In the whole animal, there is no evidence of any single population of HPP CFC that is permanently derived from a limited set of precursors.