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Klinokinesis in polymorphonuclear leucocytes.

H U Keller, G Meier, A Zimmerman

    Blood Cells
    |January 1, 1984
    PubMed
    Summary
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    Klinokinesis, a form of cell movement, was observed in leukocytes for the first time. This movement, along with orthokinesis, significantly influences polymorphonuclear leukocyte (PMN) velocity during chemotaxis.

    Area of Science:

    • Cell Biology
    • Biophysics
    • Immunology

    Background:

    • Klinokinesis, a change in turning rate, is known in microorganisms but not metazoan cells.
    • Leukocyte migration is crucial for immune responses.

    Purpose of the Study:

    • To investigate the presence and role of klinokinesis in leukocyte locomotion.
    • To analyze the combined effects of klinokinesis and orthokinesis on leukocyte speed.

    Main Methods:

    • Quantifying klinolocomotion index (KI) in human and rabbit polymorphonuclear leukocytes (PMNs).
    • Measuring changes in turning angle and frequency in response to formyl-Met-Leu-Phe (fMLP).

    Main Results:

    • Evidence for klinokinesis was found in leukocytes.

    Related Experiment Videos

  • fMLP altered KI, mean turn angle, and frequency of direction changes.
  • Synergistic effects of orthokinesis and klinokinesis on PMN velocity were observed.

    • Conclusions:

    • Klinokinesis is a component of leukocyte locomotion.
    • Both klinokinesis and orthokinesis contribute significantly to chemokinesis and PMN velocity.
    • Understanding these movement patterns is vital for chemotaxis research.