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Related Experiment Videos

An ultrastructural change in developing rat cerebral cortex: a morphometrical study.

K Tamai, K Ikari, M Hayashi

    Folia Psychiatrica Et Neurologica Japonica
    |January 1, 1983
    PubMed
    Summary

    This study reveals that as rat brains mature, axon terminals and mitochondria in the frontal cortex neuropil increase, while dendrites remain stable and synaptic terminal size decreases but numbers increase.

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    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Cell Biology

    Background:

    • The neuropil, a dense network of neuronal processes, undergoes significant ultrastructural changes during development.
    • Understanding these changes is crucial for comprehending brain maturation and function.

    Purpose of the Study:

    • To investigate age-related ultrastructural alterations in the neuropil of the rat frontal cortex (area 6) during development.
    • To quantify changes in axon terminals, dendrites, and mitochondria volume fractions and synaptic terminal characteristics.

    Main Methods:

    • Utilized five age groups of rats (1, 2, 3, 5, and 12 weeks old).
    • Acquired 500 electron micrographs from the frontal cortex neuropil (area 6) per rat.
    • Employed image analysis to trace and quantify profiles of axon terminals, dendrites, and mitochondria, calculating relative volume fractions.

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  • Assessed synaptic terminal size and number.

    • Main Results:

    • Relative volume fractions of axon terminals and mitochondria within the neuropil increased with age.
    • Relative volume fraction of dendrites remained unchanged across developmental stages.
    • Synaptic terminal size gradually decreased, while the number of terminals progressively increased.

    Conclusions:

    • Rat frontal cortex neuropil exhibits dynamic age-related ultrastructural remodeling.
    • Development involves an increase in synaptic components (terminals, mitochondria) and a decrease in terminal size, suggesting synaptic plasticity and maturation.