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[Pancreatic polypeptide (PP) (author's transl)].

R Arnold, C McIntosh, E Bothe

    Zeitschrift Fur Gastroenterologie
    |May 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

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    Radioimmunoassay can measure pancreatic polypeptide (PP) in serum. Measuring PP may help assess vagotomy effectiveness and indicate chronic pancreatitis.

    Area of Science:

    • Endocrinology
    • Gastroenterology
    • Biochemistry

    Context:

    • Pancreatic polypeptide (PP) is a peptide hormone with largely unknown physiological roles.
    • Standardized radioimmunoassay techniques allow reproducible measurement of PP in serum and tissue.

    Purpose:

    • To investigate the physiological significance of pancreatic polypeptide (PP).
    • To evaluate the clinical utility of serum PP measurements.

    Summary:

    • Serum PP levels normally increase after meals, but this increase is reportedly absent after vagotomy and reduced in chronic pancreatitis.
    • These findings suggest PP measurement could be a useful clinical tool.

    Impact:

    • Potential for PP measurement to serve as a criterion for vagotomy effectiveness.

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  • Potential for PP measurement to serve as an indicator for chronic pancreatic disease diagnosis.