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Related Experiment Videos

Intravenous premedication with diazepam. A comparison between two vehicles.

M A Mattila, M Suistomaa

    Anaesthesia
    |September 1, 1984
    PubMed
    Summary

    New diazepam formulations, Valium Roche mixed Micelles and Diazemuls, showed excellent local tolerance as intravenous premedicants, outperforming conventional preparations without compromising anxiolytic effects or systemic safety.

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    Area of Science:

    • Pharmacology
    • Anesthesiology
    • Gynecological Surgery

    Background:

    • Intravenous diazepam is used for pre-anesthetic medication.
    • Conventional diazepam preparations can cause venous irritation and thrombophlebitis.
    • Novel drug delivery vehicles may improve the local tolerance of injectable medications.

    Purpose of the Study:

    • To compare the efficacy and local tolerance of two novel diazepam formulations (Valium Roche mixed Micelles and Diazemuls) against conventional preparations.
    • To evaluate anxiolytic effects, systemic tolerance, and incidence of thrombophlebitis.

    Main Methods:

    • A comparative study involving 119 patients undergoing minor gynecological surgery.
    • Intravenous administration of Valium Roche mixed Micelles or Diazemuls as premedicants.

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  • Assessment of anxiolytic effects, systemic tolerance, and local tolerance (including thrombophlebitis).

    • Main Results:

    • No significant differences in anxiolytic effects or systemic tolerance between the two novel diazepam formulations.
    • Significantly fewer symptoms of thrombophlebitis compared to conventional diazepam preparations.
    • Both novel formulations demonstrated superior acute local tolerance compared to conventional diazepam.

    Conclusions:

    • Novel diazepam vehicles like mixed micelles and emulsified formulations offer improved local tolerance for intravenous administration.
    • These formulations are suitable alternatives for premedicant use, reducing venous irritation.
    • The use of advanced vehicles should be considered for injectable drugs prone to causing venous irritation.