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Peripheral neuropathy with vitamin B12 deficiency.

M C Kayser-Gatchalian, B Neundörfer

    Journal of Neurology
    |February 17, 1977
    PubMed
    Summary

    Vitamin B12 deficiency can cause neuropathy, affecting the peripheral nerves. Early diagnosis and understanding the link to malabsorption are key for managing this neurological condition.

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    Area of Science:

    • Neurology
    • Hematology
    • Gastroenterology

    Background:

    • Vitamin B12 deficiency is a known cause of neurological disorders.
    • Neuropathy is a significant clinical manifestation of vitamin B12 deficiency.
    • Malabsorption can contribute to vitamin B12 deficiency and subsequent neuropathy.

    Purpose of the Study:

    • To report on patients with neuropathy linked to vitamin B12 deficiency.
    • To highlight the clinical and neurophysiological diagnosis of this neuropathy.
    • To discuss the underlying pathogenesis of vitamin B12-deficiency neuropathy.

    Main Methods:

    • Case series reporting on seven patients.
    • Clinical assessment including signs of malabsorption.
    • Neurophysiological studies to confirm neuropathy.
    • Review of existing literature on pathogenesis.

    Main Results:

    • Seven patients with neuropathy associated with vitamin B12 deficiency were identified.
    • Four patients presented with additional malabsorption signs beyond an abnormal Schilling test.
    • Neuropathy diagnosis was based on comprehensive clinical and neurophysiological data.

    Conclusions:

    • Vitamin B12 deficiency is a critical cause of peripheral neuropathy.
    • Clinical presentation and neurophysiological findings are essential for diagnosis.
    • Further understanding of malabsorption's role is important in managing this condition.

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