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Plasma selenium and skin neoplasms: a case-control study.

L C Clark, G F Graham, R G Crounse

    Nutrition and Cancer
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

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    Low plasma selenium levels were associated with an increased risk of skin cancer. This finding suggests selenium may play a role in skin cancer prevention, despite challenges in studying internal cancers.

    Area of Science:

    • Oncology
    • Nutritional Biochemistry

    Background:

    • Experimental animal studies suggest selenium's potential anticancer properties.
    • Case-control studies on internal human cancers are complicated by selenium sequestration in neoplastic tissue.

    Purpose of the Study:

    • To investigate the association between plasma selenium levels and the risk of developing skin cancer.
    • To overcome the limitations of studying internal cancers by focusing on skin neoplasms with minimal tumor mass.

    Main Methods:

    • A case-control study design was employed.
    • Plasma selenium levels were measured in patients diagnosed with basal cell epithelioma, squamous cell carcinoma, or both.
    • Control groups consisted of current and past clinic patients without cancer.

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    Main Results:

    • Patients with skin cancer exhibited significantly lower mean plasma selenium levels (0.141 µg/g) compared to control subjects (0.155 µg/g).
    • The odds ratio for skin cancer was elevated in the lowest decile of selenium compared to the highest, with values of 4.39 (vs. current controls) and 5.81 (vs. past controls).

    Conclusions:

    • Lower plasma selenium levels are linked to an increased risk of skin cancer.
    • These findings support a potential role for selenium in skin cancer prevention.