Related Experiment Videos
[The cloverleaf skull. Anatomical presentation of a case]
Bulletin De L'Association Des Anatomistes
|December 1, 1984
Summary
A rare clover leaf skull syndrome, a type of craniostenosis, was observed in a stillborn infant. Reviewing 125 cases helped define the condition's key features.
Area of Science:
- Medical Genetics
- Developmental Biology
- Pediatric Pathology
Background:
- Craniostenosis encompasses premature fusion of cranial sutures, leading to abnormal skull shape.
- Clover leaf skull syndrome, a severe form of craniostenosis, presents with a characteristic trilobar appearance.
- This condition is associated with significant morbidity and mortality, often diagnosed prenatally or at birth.
Observation:
- A stillborn female infant presented with the rare clover leaf skull syndrome.
- The case involved a stillborn infant, highlighting the severe end of the spectrum for this condition.
- Detailed examination of the stillborn neonate revealed the hallmark features of clover leaf skull syndrome.
Findings:
- A comprehensive review of 125 previously reported cases was conducted.
- Analysis of prior cases allowed for a refined understanding of clover leaf skull syndrome's principal characteristics.
- Key diagnostic features and phenotypic variations of clover leaf skull syndrome were identified through case review.
Implications:
- Improved definition of clover leaf skull syndrome aids in accurate diagnosis and genetic counseling.
- Understanding the features of this rare craniostenosis can inform prenatal diagnosis and management strategies.
- This review contributes to the knowledge base for rare skeletal dysplasias and congenital anomalies.