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[Creatine phosphotransferase, B subunit, as a tumor marker. Preliminary results]
Revista Espanola De Oncologia
|January 1, 1984
Summary
Creatine kinase B (CK-B) shows potential as a tumor marker, particularly for respiratory and prostate cancers. Elevated CK-B levels correlate with specific digestive and prostate tumors, aiding diagnosis and monitoring.
Area of Science:
- Biochemistry
- Oncology
- Clinical Diagnostics
Context:
- Creatine kinase B (CK-B) is an isoenzyme with potential diagnostic applications.
- Accurate tumor markers are crucial for early cancer detection and patient management.
- Radioimmunoassay is a sensitive method for quantifying specific biomarkers.
Purpose:
- To evaluate the diagnostic utility of creatine kinase B (CK-B) as a tumor marker.
- To determine the prevalence of elevated CK-B levels in various cancer types.
- To explore the relationship between CK-B and specific tumor characteristics and progression.
Summary:
- Radioimmunoassay determined CK-B levels in 518 individuals, including controls and patients with various diseases and malignant tumors.
- Elevated CK-B (>8 ng/ml) was found in 12.6% of digestive, 6.1% of mammary, 37.7% of respiratory, and 22.2% of prostatic tumors.
- CK-B levels correlated with sigmoid flexure, liver, pancreas, and esophagus tumors, and with acid phosphatase in prostate tumors and digestive tumor evolution.
Impact:
- CK-B determination is valuable for tumors lacking established markers.
- CK-B serves as a complementary indicator in diagnosing and monitoring sigmoid flexure and prostate neoplasms.
- This research supports the use of CK-B in oncological diagnostics and patient follow-up.