Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Normocalcemic hyperparathyroidism revisited.

G V Poole, D A Albertson, R T Myers

    The American Surgeon
    |December 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Endometriosis in association with pregnancy.

    American journal of obstetrics and gynecology·2010
    Same author

    The Critical Path Institute's approach to precompetitive sharing and advancing regulatory science.

    Clinical pharmacology and therapeutics·2010
    Same author

    Has nonoperative management of solid visceral injuries adversely affected resident operative experience?

    The American surgeon·2001
    Same author

    Anal carcinoma arising from condyloma acuminata.

    The American surgeon·2001
    Same author

    Trauma patients with positive cultures have higher levels of circulating macrophage migration inhibitory factor (MIF).

    Research communications in molecular pathology and pharmacology·2001
    Same author

    Free jejunal grafts of the pharynx: surgical methods, complications, and radiographic evaluation.

    Dysphagia·1999
    Same journal

    Complete Response of Merkel Cell Carcinoma to Immunotherapy and Single-Fraction Radiotherapy Following Severe COVID-19 Infection: A Case Report and Review of Immune Mechanism.

    The American surgeon·2026
    Same journal

    Perioperative Acute Myocardial Infarction in Non-Cardiac Operations: A National Analysis.

    The American surgeon·2026
    Same journal

    Outcomes of Completion Cholecystectomy: Association With Patient Comorbidity in a National Database.

    The American surgeon·2026
    Same journal

    Building the Conversation: Editorial Stewardship in Contemporary Surgical Publishing.

    The American surgeon·2026
    Same journal

    Musculoskeletal Pain in Surgeons on Operating Days.

    The American surgeon·2026
    Same journal

    Splenectomy During Cytoreductive Surgery: Marker of Surgical Burden or Independent Predictor of Morbidity?

    The American surgeon·2026
    See all related articles

    Surgical exploration for presumed primary hyperparathyroidism in patients without persistent hypercalcemia yielded disappointing results for kidney stone recurrence. Metabolic evaluation is key to identifying patients who may benefit from parathyroid surgery.

    Area of Science:

    • Endocrinology
    • Nephrology
    • Surgical Pathology

    Background:

    • Primary hyperparathyroidism is a common cause of hypercalcemia and kidney stones.
    • Surgical exploration is the definitive treatment for primary hyperparathyroidism.
    • The management of patients with presumed hyperparathyroidism but without persistent hypercalcemia remains controversial.

    Purpose of the Study:

    • To evaluate the outcomes of cervical exploration in patients with presumed primary hyperparathyroidism but without persistent hypercalcemia.
    • To determine the efficacy of parathyroid surgery in resolving kidney stone formation in this patient population.

    Main Methods:

    • Retrospective review of 51 patients who underwent cervical exploration for presumed primary hyperparathyroidism between 1957 and 1981.

    Related Experiment Videos

  • Analysis of patient data including serum calcium levels, renal function, history of kidney stones, and parathyroid gland pathology.
  • Follow-up data on stone recurrence and resolution of hypercalcemia post-surgery.

    • Main Results:

    • Of 26 patients with hypercalciuria and normal renal function, 17 continued to form kidney stones post-exploration, regardless of parathyroid gland findings.
    • Of 25 patients with mild, intermittent hypercalcemia, 11 (with abnormal parathyroid glands) were cured of nephrolithiasis, while 10 (with normal glands) continued to form stones.
    • Surgical exploration yielded positive findings in only 19% of patients without persistent hypercalcemia.

    Conclusions:

    • Cervical exploration for "normocalcemic" hyperparathyroidism has a disappointing success rate in preventing kidney stone recurrence.
    • Metabolic evaluation is crucial to differentiate between autonomous secondary hyperparathyroidism and suppressible secondary hyperparathyroidism in stone formers.
    • Accurate patient selection through metabolic assessment is vital for identifying those who may benefit from parathyroid exploration.