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Related Experiment Videos

Spontaneous metastasis: random or selective?

L Milas, L J Peters, H Ito

    Clinical & Experimental Metastasis
    |October 1, 1983
    PubMed
    Summary
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    Metastasis potential in fibrosarcoma and mammary carcinoma did not increase with serial transplantation in mice. Tumor cell survival, not selection, likely drives spontaneous metastasis.

    Area of Science:

    • Oncology
    • Cancer Metastasis
    • Tumor Biology

    Background:

    • Spontaneous metastasis is a complex process.
    • Understanding the mechanisms driving metastasis is crucial for cancer treatment.

    Purpose of the Study:

    • To investigate whether spontaneous lung metastases from fibrosarcoma and mammary carcinoma increase in metastatic potential over serial transplant generations.
    • To determine if selection of preexisting metastatic variants or random survival of intravasated tumor cells is the primary driver of metastasis.

    Main Methods:

    • Fibrosarcoma and mammary carcinoma models were used.
    • Tumors were serially transplanted into syngeneic mice for up to six generations.
    • Both normal and whole-body-irradiated mice were utilized.
    • Metastatic potential was assessed by evaluating lung metastases.

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    Main Results:

    • No increased metastatic capacity was observed in serially transplanted tumors.
    • Metastatic efficiency tended to decrease over successive generations.
    • Metastatic behavior varied between tumor types and transplant generations.

    Conclusions:

    • Spontaneous metastasis is likely determined by the random survival of intravasated tumor cells.
    • Selection of pre-existing metastatic variants plays a less significant role than previously thought.
    • These findings challenge traditional views on the evolution of metastatic potential in tumors.