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Vitamin D conversion by sarcoid lymph node homogenate.

R S Mason, T Frankel, Y L Chan

    Annals of Internal Medicine
    |January 1, 1984
    PubMed
    Summary
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    Sarcoidosis patients have high calcitriol levels, potentially from non-kidney sites. Sarcoid lymph nodes convert calcifediol to calcitriol, unlike normal nodes.

    Area of Science:

    • Endocrinology
    • Immunology
    • Biochemistry

    Background:

    • Hypercalcemia in sarcoidosis is linked to elevated calcitriol (1,25-dihydroxyvitamin D).
    • The extra-renal synthesis of calcitriol in sarcoidosis is a proposed mechanism.

    Observation:

    • This study investigated the potential for extra-renal calcitriol synthesis in sarcoidosis.
    • Lymph node homogenates from sarcoidosis patients and controls were analyzed for vitamin D metabolism.

    Findings:

    • Sarcoid lymph node homogenates successfully metabolized calcifediol (25-hydroxyvitamin D) into a substance identical to calcitriol.
    • Lymph nodes from non-sarcoid individuals did not exhibit this metabolic activity.

    Implications:

    • Provides direct evidence for local calcitriol production within sarcoid lymph nodes.

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  • Suggests a potential therapeutic target for managing hypercalcemia in sarcoidosis.