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Related Experiment Videos

Decrease of peripheral large granular lymphocytes in Graves' disease.

Y Iwatani, N Amino, O Kabutomori

    Clinical and Experimental Immunology
    |January 1, 1984
    PubMed
    Summary

    Peripheral large granular lymphocytes (LGL) are significantly reduced in women with active Graves' disease. This reduction may contribute to the ongoing thyrotoxicosis in these patients.

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    Area of Science:

    • Immunology
    • Endocrinology
    • Thyroid disease research

    Background:

    • Peripheral large granular lymphocytes (LGL) play a role in immune regulation.
    • Autoimmune thyroid diseases, such as Graves' disease (GD) and Hashimoto's disease (HD), involve complex immune system dysregulation.
    • LGL levels may be altered in various autoimmune conditions.

    Purpose of the Study:

    • To investigate the levels of peripheral large granular lymphocytes (LGL) in patients with autoimmune thyroid diseases compared to healthy individuals.
    • To determine if LGL counts correlate with thyroid hormone levels or disease activity in Graves' disease and Hashimoto's disease.

    Main Methods:

    • Enumeration of peripheral large granular lymphocytes (LGL) in blood samples.
    • Comparison of LGL percentages and absolute counts between normal subjects and patients with Graves' disease (GD) and Hashimoto's disease (HD).

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  • Correlation analysis between LGL levels and serum thyroid hormone concentrations (T4, T3), anti-thyroid antibody titres, goitre size, and proptosis severity.

    • Main Results:

    • Normal women had lower LGL percentages than normal men.
    • Untreated thyrotoxic Graves' disease patients exhibited significantly lower percentages and absolute counts of LGL compared to normal women.
    • No significant differences in LGL levels were found in treated euthyroid GD patients or patients with Hashimoto's disease (euthyroid or hypothyroid).
    • LGL percentage inversely correlated with serum T4, T3, and free T4 index in untreated GD and HD patients.

    Conclusions:

    • A significant decrease in peripheral large granular lymphocytes (LGL) is observed in patients with active, thyrotoxic Graves' disease.
    • The reduced LGL levels in thyrotoxicosis may be linked to the self-perpetuating nature of the condition.
    • LGL counts do not appear to be significantly affected by Hashimoto's disease or treated Graves' disease.