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Related Experiment Videos

Rapid searches for complex patterns in biological molecules.

R M Abarbanel, P R Wieneke, E Mansfield

    Nucleic Acids Research
    |January 11, 1984
    PubMed
    Summary
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    Searching for patterns in genetic data is challenging due to information redundancy. A new program, QUEST, enables rapid searching of DNA and protein databases for complex, ambiguous sequence patterns.

    Area of Science:

    • Bioinformatics
    • Computational Biology
    • Genomics

    Background:

    • Biological sequences (DNA, protein) contain intrinsic redundancy, complicating pattern identification.
    • Efficiently searching large genetic databases for specific patterns is a significant challenge in bioinformatics.

    Purpose of the Study:

    • To introduce QUEST, an interactive, self-documenting computer program designed for rapid pattern searching in biological sequence data.
    • To enable the identification of highly redundant consensus sequences and complex character patterns within large DNA and protein databases.

    Main Methods:

    • Development of QUEST, a program utilizing a concise, flexible language for pattern specification.
    • Implementation of algorithms for handling multiple levels of ambiguity and pattern arrangement in sequence queries.

    Related Experiment Videos

  • Application of QUEST to search large DNA and protein data banks.

    • Main Results:

    • QUEST facilitates rapid searching of extensive biological sequence data.
    • The program effectively identifies highly redundant consensus sequences and character patterns.
    • Demonstrated utility of QUEST through examples of its application to sequence data analysis.

    Conclusions:

    • QUEST provides an efficient solution for pattern discovery in redundant genetic information.
    • The program's flexible pattern language and optimized algorithms enhance the analysis of large biological sequence datasets.
    • QUEST is a valuable tool for researchers working with DNA and protein sequence data.