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Computer programs for handling nucleic acid sequences.

C Keller, M Corcoran, R J Roberts

    Nucleic Acids Research
    |January 11, 1984
    PubMed
    Summary
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    New bioinformatics programs visualize DNA restriction maps and reading frames. Upgraded software offers online GENBANK access for DNA sequence analysis and automated DNA assembly.

    Area of Science:

    • Bioinformatics
    • Computational Biology
    • Molecular Biology

    Background:

    • Advancements in DNA sequencing generate vast amounts of genetic data.
    • Efficient analysis tools are crucial for interpreting complex biological information.
    • High-resolution graphics terminals enable detailed visualization of molecular data.

    Purpose of the Study:

    • To develop and upgrade bioinformatics software for enhanced DNA sequence analysis.
    • To improve the visualization of genetic data, including restriction enzyme maps and open reading frames.
    • To facilitate online access to comprehensive DNA sequence databases like GENBANK.

    Main Methods:

    • Development of specialized programs for displaying restriction enzyme maps and open translational reading frames.

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  • Utilization of high-resolution graphics terminals (Retrographics VT640) for data visualization.
  • Upgrading existing software to support online access to the National Institutes of Health (NIH) GENBANK database.
  • Enhancing programs to handle DNA sequences of arbitrary lengths.
  • Advancing the automation of DNA assembly processes.

    • Main Results:

    • Accurate graphical display of restriction enzyme maps and open translational reading frames achieved.
    • Online access to GENBANK integrated, enabling comprehensive DNA sequence retrieval and analysis.
    • Software enhanced to process DNA sequences of any length, overcoming previous limitations.
    • Significant progress in the automation of DNA assembly programs reported.
    • Improved user interface and data handling capabilities for molecular biologists.

    Conclusions:

    • The developed and upgraded bioinformatics programs provide powerful tools for DNA sequence analysis and visualization.
    • Online access to GENBANK and the ability to process long sequences significantly enhance research capabilities.
    • Automation in DNA assembly promises increased efficiency in genetic engineering and synthetic biology.
    • These advancements contribute to the broader field of genomics and molecular biology research.