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Related Experiment Videos

Microcomputer programs for graphic analysis of nucleic acid and protein sequences.

D W Mount, B Conrad

    Nucleic Acids Research
    |January 11, 1984
    PubMed
    Summary

    This study introduces four C programming language tools for comparing DNA and amino acid sequences. These programs visualize sequence homology, repeats, and symmetry, offering flexible options for various printers and systems.

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    Area of Science:

    • Bioinformatics
    • Computational Biology
    • Genomics

    Background:

    • Sequence comparison is fundamental to understanding biological function.
    • Identifying homology, repeats, and symmetry aids in gene and protein analysis.
    • Existing tools may lack flexibility or specific visualization capabilities.

    Purpose of the Study:

    • To present four novel computer programs for sequence analysis.
    • To enable visualization of sequence homology, repeats, and dyad symmetry.
    • To offer user-friendly options for diverse computational and printing environments.

    Main Methods:

    • Development of four distinct computer programs in C.
    • Implementation of 2D array display for homology results.
    • Inclusion of options for partial sequence analysis, windowing, and codon-specific matching.
    • Compatibility with standard printers and graphics-capable printers.

    Main Results:

    • Programs effectively compare amino acid and DNA sequences for homology.
    • Visualization of repeated sequences and dyad symmetry is achieved.
    • Flexible options allow tailored analysis, including base-specific matching.
    • Software runs on CP/M 80 and is available for IBM/PC.

    Conclusions:

    • The developed programs provide versatile tools for sequence analysis.
    • These programs enhance the ability to study sequence relationships and structures.
    • The software is accessible and adaptable for researchers in bioinformatics and related fields.

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