Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins.

S M Hedrick, E A Nielsen, J Kavaler

    Nature
    |March 8, 1984
    PubMed
    Summary

    The study suggests a T-cell receptor (TCR) chain is encoded by the TM86 cDNA clone. This finding is based on sequence similarities to immunoglobulin proteins and evidence of gene rearrangements.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A fasting-mimicking diet in patients with mild-to-moderate Crohn's disease: a randomized controlled trial.

    Nature medicine·2026
    Same author

    Effect of Ligand Modification on the Mechanism of Electrocatalytic Hydrogen Production by Ni(pyridinethiolate)<sub>3</sub><sup>-</sup> Derivatives.

    The journal of physical chemistry. A·2018
    Same author

    Mass cytometry identifies a distinct monocyte cytokine signature shared by clinically heterogeneous pediatric SLE patients.

    Journal of autoimmunity·2017
    Same author

    The Missing -Omes: Proposing Social and Environmental Nomenclature in Precision Medicine.

    Clinical and translational science·2017
    Same author

    Curing the historically incurable: treatment success with ledipasvir/sofosbuvir for chronic hepatitis C virus in a heavily treatment-experienced individual.

    Journal of clinical pharmacy and therapeutics·2016
    Same author

    Increasing incidence and geographic distribution of neonatal abstinence syndrome: United States 2009 to 2012.

    Journal of perinatology : official journal of the California Perinatal Association·2015

    Area of Science:

    • Immunology
    • Molecular Biology
    • Genetics

    Background:

    • T cells play a crucial role in adaptive immunity.
    • The T-cell receptor (TCR) mediates antigen recognition by T cells.
    • Understanding TCR structure is vital for immunology research.

    Purpose of the Study:

    • To identify the molecular components of the T-cell receptor.
    • To analyze the sequence of a T cell-specific cDNA clone (TM86).
    • To investigate the genetic basis of TCR diversity.

    Main Methods:

    • Sequence comparison of cloned T cell-specific cDNA (TM86) with other cDNAs.
    • Isolation of cDNAs from a thymocyte library.
    • Analysis of sequence homology and structural regions.

    Related Experiment Videos

    Main Results:

    • The TM86 cDNA clone exhibits variable, constant, and joining regions.
    • These regions show remarkable similarity in size and sequence to immunoglobulin encoding genes.
    • Evidence of somatic gene rearrangements supports the findings.

    Conclusions:

    • The TM86 cDNA clone likely encodes a chain of the T-cell receptor for antigen.
    • The structural similarities suggest a shared evolutionary or functional basis between TCR and immunoglobulin proteins.
    • This finding contributes to the understanding of T-cell receptor structure and function.