[Oxygen metabolism (based on polarographic data) in patients with thyroid diseases]

The results are presented of the studies of oxygen metabolism in the muscular tissue of patients with the thyroid goiter formation. An original method of the polarographic study allows one to observe the process of oxygen transport not only from the intracellular space into the cell, but also from the blood channel into the intracellular space. Oxygen utilization curve was recorded after prolonged ischemia (15 minutes) the oxygen recovery curve was noted, according to which the oxygen recovery rate coefficient, allowing to judge the circulation time and the vascular wall permeability, was counted by analogy with oxygen utilization rate determination. The ratio of these coefficients was used as an index for the tissue supplying with oxygen. The data are presented of studying 105 patients with different forms of the thyroid goiter formation. The informativeness of the utilization rate coefficient is examined for evaluating oxygen consumption by tissues. This index was practically equal in patients with diffuse toxic goiter, nodose euthyroid goiter and in the controls. At the same time the coefficient of oxygen recovery rate and the coefficient ratio of oxygen recovery and utilization rates were significantly elevated in patients with diffuse toxic goiter (1.3 +/- 0.21, 4.33 +/- 0.76) in comparison with the patients suffering from nodose euthyroid goiter (0.72 +/- 0.2, 2,95 +/- 0.66) and the controls (0.67 +/- 0.18, 1.8 +/- 0.37). In the patients with diffuse toxic goiter these indices returned to normal (0.44 +/- 0.11, 1.57 +/- 0.63) following the preoperative preparation.