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Related Experiment Videos

Biostatistical parameters of paternity and calculation by a computer programme.

H H Hoppe, D Körnig, P J Lincoln

    Forensic Science International
    |April 1, 1984
    PubMed
    Summary

    This study defines biostatistical parameters for disputed paternity cases, including probability of paternity (POP) and paternity index (PI). A computer program was developed to calculate these parameters using up to 24 marker systems.

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    Area of Science:

    • Forensic genetics
    • Biostatistics
    • Paternity testing

    Background:

    • Disputed paternity cases require robust biostatistical analysis.
    • Established parameters like Paternity Index (PI) are crucial for evaluating evidence.
    • Accurate calculation of these parameters is essential for legal and clinical contexts.

    Purpose of the Study:

    • To define and discuss key biostatistical parameters used in disputed paternity investigations.
    • To introduce a novel computer program for calculating these parameters.
    • To facilitate accurate paternity assessment using multiple genetic marker systems.

    Main Methods:

    • Definition and discussion of biostatistical parameters: paternal markers in the child (PM), individual exclusion change (IEC), probability of incidental involvement (Z), probability of paternity (POP), plausibility of paternity according to Essen-Möller (PLEM), and paternity index (PI).

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  • Development of a computer program in BASIC for parameter calculation.
  • Inclusion of up to 24 marker systems, including HLA, with consideration of linkage disequilibrium.

    • Main Results:

    • The study provides a framework for understanding and applying essential biostatistical parameters in paternity testing.
    • A functional computer program is available for calculating complex paternity indices.
    • The program accommodates a large number of genetic markers, enhancing analytical power.

    Conclusions:

    • The developed biostatistical parameters and the accompanying computer program offer a comprehensive tool for resolving disputed paternity cases.
    • Accurate calculation of parameters like POP and PI is vital for forensic and legal decision-making.
    • The integration of multiple marker systems, including HLA, improves the reliability of paternity assessments.