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Development of individual insulin infusion profiles for open loop infusion systems
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|April 1, 1984
Summary
A novel computer-controlled insulin pump delivers insulin using a wavy step profile, mimicking natural insulin secretion. This advanced system effectively controlled blood sugar in diabetic patients, offering potential for improved diabetes management.
Area of Science:
- Biomedical Engineering
- Endocrinology
- Diabetology
Background:
- Diabetes management often struggles with precise insulin delivery to mimic physiological secretion.
- Traditional insulin therapy can lead to suboptimal glycemic control and complications.
- Developing advanced insulin infusion systems is crucial for better patient outcomes.
Purpose of the Study:
- To evaluate a computer-controlled insulin infusion pump using a novel wavy step profile.
- To assess the efficacy of this system in controlling blood glucose in insulin-dependent diabetics.
- To explore the potential of simulated closed-loop control algorithms for insulin therapy.
Main Methods:
- Utilized a computer-controlled syringe-type insulin pump with programmable rates and meal programs.
- Implemented a wavy step infusion profile based on the biphasic insulin secretion model.
- Simulated closed-loop control using an algorithm based on theoretical postprandial glucose profiles.
- Administered intravenous open-loop insulin infusion to fifteen juvenile-onset diabetics.
Main Results:
- Achieved good glycemic control in unstable juvenile-onset diabetics within 2-3 days.
- Demonstrated the effectiveness of basal rates combined with meal-activated wavy step profiles.
- Showed that a preabsorptive cephalic phase bolus improved postprandial control and reduced insulin needs.
Conclusions:
- The programmable insulin infusion device is a valuable tool for sophisticated insulin delivery.
- The wavy step profile effectively mimics physiological insulin secretion.
- This system shows promise for both open-loop and future closed-loop insulin infusion systems.