Evaluation and comparison of the renal excretory function after different diuretics through criteria based on a...

The subject of the present study is to compare various diuretic effects through a number of criteria included in a programme developed by us on the basis of an improved model of the method of W.P. Leary and A.J. Reyes for description of the dynamics of the renal excretory function. The effects compared were: of diuretics different in potency and duration of action; of different doses of one and the same diuretic; of different diuretics and placebo--0.9% solution of sodium chloride. The rate of excretion prior to the diuretic administration is graphically represented which enables the estimation of presence or absence of diuretic effect of the pharmacological substance applied. This also makes possible the evaluation of the specific effect of the diuretics with regard to different electrolytes which improves the approach when the diuretics are to be combined and helps their optimum dosage and distribution within time.