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A probit analysis program for the personal computer.

G M Schoofs, C C Willhite

    Journal of Applied Toxicology : JAT
    |June 1, 1984
    PubMed
    Summary
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    A new PASCAL program offers an economical and convenient way to calculate dose-response curve parameters on microcomputers. This software accurately determines median effective doses and potency ratios, simplifying toxicological data analysis.

    Area of Science:

    • Pharmacology
    • Toxicology
    • Biostatistics

    Background:

    • Quantal dose-response curve analysis is crucial in pharmacology and toxicology.
    • Manual calculation methods can be time-consuming and prone to error.
    • Microcomputer-based solutions offer potential for increased efficiency and accessibility.

    Purpose of the Study:

    • To present a PASCAL language application software for calculating key parameters of quantal dose-response curves.
    • To provide an economical and convenient microcomputer-based tool for toxicological dose-response analysis.
    • To compare the software's results with established methods for calculating LD50 and potency ratios.

    Main Methods:

    • Development of a PASCAL program for microcomputers.
    • The software calculates median effective doses (LD50), confidence limits, potency ratios, and slopes.

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  • Simultaneous analysis of up to 20 treatments and 100 doses.
  • Comparison with a commercial probit analysis program and manual methods using thiopental and phenobarbital data in mice.

    • Main Results:

    • The PASCAL program provides economical and convenient calculations for dose-response parameters.
    • The software accurately calculates LD50, confidence limits, and potency ratios.
    • Results from the PASCAL program show good agreement with established manual and commercial probit analysis methods.
    • Calculations for parallelism and potency ratios between thiopental and phenobarbital are demonstrated.

    Conclusions:

    • The developed PASCAL software is a viable, efficient, and accessible tool for quantal dose-response analysis on microcomputers.
    • This application simplifies complex statistical calculations in toxicology and pharmacology.
    • The program's compatibility and accuracy make it a valuable resource for researchers.